Course syllabus for

Chemical Biology, 8 credits

Kemisk biologi, 8 hp
This course syllabus is valid from spring 2023.
Please note that the course syllabus is available in the following versions:
Spring2018 , Spring2021 , Spring2022 , Spring2023
Course code
1BI039
Course name
Chemical Biology
Credits
8 credits
Form of Education
Higher Education, study regulation 2007
Main field of study 
Biomedicine 
Level 
G2 - First cycle 2 
Grading scale
Fail (U), pass (G) or pass with distinction (VG)
Department
Department of Medical Biochemistry and Biophysics
Decided by
Programnämnden för biomedicinprogrammen
Decision date
2017-11-02
Revised by
Programme committee for study programmes in biomedicine
Last revision
2022-10-18
Course syllabus valid from
Spring 2023

Specific entry requirements

At least the grade Pass (G) on the course Introduction to Biomedical Science, at least grade Pass (G) on the part Organic-chemical laboratory work, (5 credits), in the course General and Organic Chemistry, and the part Laboratory practicals (4 credits) of the course Cell-, stem cell and developmental biology, at the Bachelor's programme in Biomedicine

Objectives

Upon completion of the course, the student should be able to:

Regarding knowledge and understanding:

  • describe structures of biological macromolecules and explain at a basic level the most commonly occurring methods for determination and analysis of the three-dimensional structure of biomolecules,
  • explain biophysical and chemical methods that are used to study the regulation and function of biomolecules,
  • account for how chemical biology methods are used within biomedical research and pre-clinical drug discovery,
  • discuss the use of chemical biology in biomedical research and pre-clinical drug discovery,

Regarding competence and skills:

  • carry out and orally present chemical biology projects,
  • perform basic chemical biology laboratory work safely and according to instructions,
  • describe and analyse their own chemical biology laboratory work,
  • analyse macromolecular structures,

Regarding judgement and approach:

  • follow scientific ethical guidelines when documenting data and results,
  • assess, evaluate and choose appropriate methods for basic chemical biology experiments.

Content

The course content is oriented towards chemical biology aspects of pre-clinical drug discovery as well as towards study of biological systems.

The course is divided into the following 2 parts:

Chemical biology project work and laboratory work, 4.0 hp

Grading scale: GU

Cover a chemical biology topic from different perspectives. Oral presentation of findings.

Commonly used methods in chemical biology laboratory work and computational data analysis. Written lab reports.

Integration of theory and practice, 4.0 hp

Grading scale: VU

Integration of theory and practice of chemical biology.

Teaching methods

The teaching includes lectures, laboratory sessions, computer laboratory sessions, group tuition (seminars) and project work. An emphasis is placed on problem-solving.

Examination

Part 1. Chemical biology project work and laboratory work (4 credits). The examination consists of oral presentation of the project work. Graded Fail/Pass. The examination of the laboratory work consists of written lab reports. Graded Fail/Pass/Pass with distinction.
 
Part 2. Integration of theory and practice (4 credits). The examination consists of a written exam covering the entire contents of the course. Graded Fail/Pass/Pass with distinction.
 
To pass the whole course the grade of at least pass must have been obtained for all parts of the course. To obtain a final grade of "Pass with distinction", a grade of "Pass with distinction" must be obtained for both the part "Integration of theory and practice" and the laboratory element of the part "Chemical biology project work and laboratory work".
 
Students that fail to submit compulsory assignments by the deadlines will lose the opportunity to be graded with pass with distinction on the course.

Compulsory participation
Laboratory sessions are compulsory, as well as other teaching occasions linked to these parts. Participation in regular project work discussions is compulsory. The course director assesses if and, in that case, how absence can be compensated. Before the student has participated in all compulsory parts or compensated absence in accordance with the course director's instructions, the student's results for respective part will not be registered in LADOK. Absence from a compulsory part may lead to that the student can't compensate the absence before the next time the course is given.

Limitation of number of examinations or practical training sessions
Students who have not passed the regular examination are entitled to participate in five more examinations. If the student has failed six examinations/tests, no additional examination or new admission is provided.
The number of times that the student has participated in one and the same examination is regarded as an examination session. Submission of a blank examination is regarded as an examination. An examination, for which the student registered but not participated in, will not be counted as an examination.

If there are special grounds, or a need for adaptation for a student with a disability, the examiner may decide to deviate from the syllabus's regulations on the examination form, the number of examination opportunities, the possibility of supplementation or exemptions from the compulsory section/s of the course etc. Content and learning outcomes as well as the level of expected skills, knowledge and abilities may not be changed, removed or reduced.

Other directives

The course language is English.

Course evaluation will be carried out in accordance with the guidelines established by the Board of Higher Education.

Oral evaluation in the form of course council meetings will be carried out during the course.

Literature and other teaching aids

Mandatory literature

Specific material referred to during the course forms the course literature.

Recommended literature

Miller, Andrew; Tanner, Julian Essentials of chemical biology : structure and dynamics of biological macromolecules
Van Vranken, David L.; Weiss, Gregory A. Introduction to bioorganic chemistry and chemical biology
Structure-Based Drug Discovery [Elektronisk resurs]
Schmidt, Marco F. Chemical Biology : And Active Ingredient Development
Drug Design : Structure- and Ligand-Based Approaches Merz, Kenneth M.; Ringe, Dagmar; Reynolds, Charles H.