Biostatistics, 4.5 credits

At least the grade pass at the courses Introduction to Biomedical Science, and General and Organic Chemistry, and at least the grade pass at the parts Basal metabolism (3 credits) and Biochemical laboratory methods (2 credits) of the course Medical Biochemistry, and the part Cell biology (6 credits) of the course Cell Biology and Genetics, within the Bachelor's Programme in Biomedicine.

The aim of the course is to give students knowledge of basic statistical concepts and tools that can be used to understand results published in scientific literature and to perform their own statistical analyses.

Upon completion of the course the student should be able to:

Regarding knowledge and understanding

• explain the concept of random variation in biological phenomena and how it is related to observational and experimental studies,
• describe appropriate statistical methods to quantify random and systematic effects in biological data,
• discuss (at an elementary level) the relevance of statistical inference for empirical research.

Regarding competence and skills

• choose and apply statistical methods to address research questions by means of statistical software,
• communicate statistical results in oral presentations and scientific publications,
• interpret and discuss statistical findings of basic complexity in relevant scientific literature.

Regarding judgement and approach

• assess scientific hypotheses based on empirical proofs.

Data types: nominal, ordinal and continuous variables. Descriptive measures. Graphical presentation. Randomness in biological observations. Statistical thinking around randomness. Data from experiments and observational studies. Probability concepts. Probability distributions: coin, dice, Poisson, Binomial, Exponential, Normal, Student’s t. Parameter estimation: mean and proportion. Quantification of statistical uncertainty: standard error, confidence intervals and hypothesis testing. Elementary hypothesis testing: Z-tests, t-tests. Elementary considerations concerning power and samples size.

Correlation and linear regression. Statistical models. Verification of model assumptions. Robust (non-parametric and distribution free) methods. Analysis of contingency tables. 
 

Teaching will be in the form of lectures and practical computer activities.

The examination consists of written examination.

Compulsory attendance
Attendance is compulsory during the introduction to the course and practical computer activities. The course director decides if and in that case, how absence may be compensated. Before the student has participated in compulsory parts, or compensated absence in accordance with the course director's instructions the student's results will not be registered in LADOK.

Limited number of examinations or practical training sessions
Students who have not passed the regular examination are entitled to participate in five more examinations. If the student has failed six examinations/tests, no additional examination or new admission is provided.

The number of times that the student has participated in one and the same examination is regarded as an examination session. Submission of a blank examination is regarded as an examination. An examination for which the student registered but not participated in, will not be counted as an examination.

After each course occasion there will be at least six occasions for the examination within a two-year period from the end of the course.

The course language is English.

Course evaluation will be carried out in accordance with the guidelines established by the Board of Higher Education.

Oral evaluation in the form of course council meetings will be carried out during the course.