For students attending the Master's Programme in Toxicology Past Master thesis projects

Potential projects with a toxicological profile are usually presented during the spring on semester 2. Projects can also be found at various websites at KI and other universities and the students are encouraged to make their own contacts, e.g. teachers at previous courses. Projects may be performed at KI and other internationally recognized universities, pharmaceutical, chemical or consultancy companies or governmental authorities/agencies.

The project can be either an experimental, epidemiological or a literature-based research project or a risk assessment-related project and are usually 37.5 credits.

Below is a list of some of the projects performed recently (Class of 2026).

• A novel antioxidants as Prophylactic Treatment to Attenuate Graft-versus-Host Disease. @ Karolinska Institutet
• A transposon mutagenesis study in Pseudomonas aeruginosa clone C. @ Karolinska Institutet
• Assessing the Feasibility of Microsampling for Measurement of PFAS in Human Blood. @ Karolinska Institutet
• Assessing the Impact of Glucocorticoid Receptor-Mediated Endocrine Disruption on Mouse and Human Neurodevelopmental In Vitro Models. @ Uppsala University
• Association between biomarkers of acrylamide and long-term risk of dementia. @ Karolinska Institutet
• Chemicals and equity – the role of socioeconomic factors in exposure and health risks. @ Public Health Agency of Sweden
• Cytotoxicity assessment of rare earth metal nanoparticles using human lung cells. @ Karolinska Institutet
• Data-derived uncertainty factors for hepatoxicity based on early cellular effects. @ Karolinska Institutet
• Decoding upstream cell death pathways driving ASO toxicity in non-hepatic models. @ AstraZeneca
• Detection of illicit Drugs and Pharmaceuticals in Hair using LC-MS/MS - Validation and Revision of Methods. @ Forensisch Toxikologisches Centrum GmbH, Munich, Germany
• Effect of endocrine disruptive chemicals on human hypothalamic neuron differentiation and function. @ Karolinska Institutet
• Examination of gene–smoking interaction variants and their role in lung function in sarcoidosis. @ Karolinska Institutet
• Extracellular vesicle signatures of endocrine disruptor effects on embryo development in a stem cell-based model. @ Karolinska Institutet
• IL-26 in lung macrophages derived from long-term tobacco smokers with or without Chronic Obstructive Pulmonary Disease. @ Karolinska Institutet
• In Silico Modelling of Aquatic Toxicity. @ Research Institutes of Sweden
• Interrogating the effects of environmental factors on the expression of non-coding region variants linked to IBD risk using zebrafish. @ Karolinska Institutet
• Investigating the Impact of Antibiotic Treatment on Mitochondrial Dynamics in Developing Neuronal Cells. @ Karolinska Institutet
• Investigating the role of UNG2 and APOBEC3A/B in cellular responses to drug-induced toxicity. @ Karolinska Institutet
• Investigation of potential endocrine disruption activity for selective industrial chemicals within the REACH and CLP regulation. @ Perstorp
• Next-generation pregnancy PBK model for PFAS - Mechanistic incorporation of toxicokinetic processes using in vitro data. @ Swedish University of Agricultural Sciences
• Physicochemical Properties and Bioaccessibility of Metals in Lithium-Ion Battery Black Mass: Implications for Skin Exposure and Risk Assessment. @ Swedish Environmental Research Institute
• Prediction of PFAS serum levels in the adult population by Bayesian modelling: Incorporating temporal trends and drinking water exposure scenarios. @ Swedish University of Agricultural Sciences
• Regulation of frataxin expression in human liver spheroids and implications for oxidative stress and ataxia. @ Karolinska Institutet
• Role of tRNA regulation in cellular responses under stress. @ University of Cambridge, UK
• The mechanistic role of interleukin-9 in modulating airway hyperresponsiveness in isolated human/animal small airways. @ Karolinska Institutet
• The mental health effects of fetal, childhood, and adolescent exposure to toxic metals: A 20-year follow-up study of the MINIMat trial in rural Bangladesh. @ Karolinska Institutet
• The role of two isoforms of the transcription factor ID1 (specifically ID1b) and the interaction with Kif11 in squamous cell carcinomas. @ Karolinska Institutet
• Toxic Responses to Amazon Wildfire Particles in a Pulmonary Co-Culture Model. @ Karolinska Institutet
• Toxicological and functional assessment of novel histone deacetylase inhibitors in a genetic zebrafish model of tumorigenesis. @ Karolinska Institutet
• Use of Human Liver Spheroids to Predict siRNA Drug Specificity, Toxicity, Stability and Metabolism. @ Karolinska Institutet